Expression of granule-associated proteins in neutrophils from patients with severe congenital neutropenia.
نویسندگان
چکیده
In a recent publication in Blood, Donini et al1 conclude that granulocyte colony-stimulating factor (G-CSF) treatment of severe congenital neutropenia (SCN) results in abnormal expression of granule-associated proteins. We have previously published this concept,2 and showed that neutrophils from patients with SCN lack the antimicrobial peptide LL-37 and have reduced levels of defensins (HNP1–3), but are functionally capable of both phagocytosis and generating oxidative
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عنوان ژورنال:
- Blood
دوره 110 7 شماره
صفحات -
تاریخ انتشار 2007